Stereoselective Total Synthesis of an Anti-Fouling Agent, C2-Symmetricnatural Macrolide Trichobotryside A
K. Nagi Reddy
Research Scholar, Department of Chemistry, Mahatma Gandhi University, Nalgonda and Assistant Professor of Chemistry, KRR Government Arts and Science College (A), Kodad, Telangana.
Mandala Jyothi
Department of Chemistry, Mahatma Gandhi University, Nalgonda, Telangana, India
23-32
Vol: 16, Issue: 1, 2026
Receiving Date:
2025-11-19
Acceptance Date:
2025-12-31
Publication Date:
2026-01-17
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http://doi.org/10.37648/ijrst.v16i01.003
Abstract
A stereoselective total synthesis of 16-membered macrodiolide trichobotryside A has been successfully completed. The key features are: Evans’ Crotylation, regioselective epoxide opening, Wardsworth-Emmons-Horner Olefination and Mitsunobu Reaction.
Keywords:
Macrodiolide; anti-fouling agent; Evans’ Crotylation; Super Hydride; regioselective epoxide opening; Wardsworth-Emmons-Horner Olefination; Mitsunobu Reaction
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