A One-Pot, Three-Component Efficient New Synthesis of Pyrrolo-[3,2-D] Isoxazole Derivatives Catalyzed by L-Proline in Acetic Acid Media
K Thirupathaiah
Department of Chemistry, M. V. S. Government Arts and Science College (A), Mahabubnagar, Telangana, India.
R Lavanya
Department of Chemistry, N. T. R. Government Degree College (W), Mahabubnagar, Telangana, India.
G Satyanarayana Goud
Department of Chemistry, M. V. S. Government Arts and Science College (A), Mahabubnagar, Telangana, India.
80-87
Vol: 12, Issue: 2, 2022
Receiving Date:
2022-04-09
Acceptance Date:
2022-05-22
Publication Date:
2022-06-20
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http://doi.org/10.37648/ijrst.v12i02.009
Abstract
A one-pot, three-component reaction of 4-hydroxy coumarin, arylglyoxals, and 5-amino-3-methylisoxazole in the presence of L-proline as an organocatalyst in acetic acid under reflux conditions provides a series of new pyrrolo [3,2-d] isoxazole derivatives (4a-l) in excellent yields.
Keywords:
One-pot synthesis; L-proline catalyst; Arylglyoxals; Efficient new synthesis; Pyrrolo[3,2-d]isoxazoles.
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