α-Amidoalkylation reaction is a powerful tool of modern organic synthesis for carbon-carbon or carbon-heteroatom bond formation. The distinguishing features of amidoalkylating reagents are higher electrophilicity and wider structural diversity compared with those of reagents involved in aminoalkylation reactions. Therefore, amidoalkylation has been extensively applied in the synthesis of various nitrogencontaining acyclic and heterocyclic compounds including bioactive natural products (e.g., alkaloids, antibiotics, toxins, vitamins) and pharmaceuticals. Recently, some enantioselective variants of this reaction employing catalytic amounts of chiral auxiliaries has also been described.

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