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ENDOCRINOLOGICAL DISORDER & ENDOCRINE MYOPATHY DEVELOPED BY IMBALANCES OF CREATINE KINASE &VARIOUS HORMONES

Mulla Javed Bakas

Assistant Professor, Endocrinology Dept. of Biochemistry, Naraina Medical College& Research Centre, Kanpur

71-85

Vol: 5, Issue: 3, 2015

Receiving Date: 2015-05-22 Acceptance Date:

2015-06-21

Publication Date:

2015-07-22

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Abstract

All kind of endocrinopathy is generally associated with hormonally-mediated systemic disorders. Myopathy is a result of this association and sometimes can be the first manifestation of endocrine diseases. This condition generally misdiagnosed as weakness and diagnosis and treatment of endocrine diseases are delayed. Especially cushing’s disease, exogen glucocorticoid use, hypothyroidism, hyperaldesteronism and osteomalacia can mimic inflammatory myopathies clinically. Endocrine myopathies are of disease which must be part of differential diagnosis who has proximal muscle weakness. Statin and glucocorticoid use come to the knowledge of physician because these are the most common cause of drug related proximal myopathy. While evaluating patient with proximal myopathy, thyroid function tests, vitamin D levels, parathyroid hormone must be measured and primary hyperaldesteronism work up when clinically suspicion occurs. Treatment of endocrine myopathies are based on correction of endocrine disorder.

Keywords: Endocrine myopathy,Vitamin D,CK Creatine Kinase,Cushing’s disease,Parathyroid hormone,Primary hyperaldesteronism

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